Medical-Pharmaceutical Literature related to Wolfgang Scholz, Founder and Editor of SCHOLZ DataBank
Ulrich Ruben Luecht, Wolfgang Scholz, Ann-Kathrin Geiben, Ekkehard Haen and Georg Hempel;
Physiologically Based Pharmacokinetic Model of CYP2D6 Associated Interaction Between Venlafaxine and Strong Inhibitor Bupropion—The Influence of Age-Relevant Changes and Inhibitory Dose to Classify Therapeutical Success and Harm
*******
Scholz W. Loperamide: Death by Lemonade and Conclusions for E-prescribing. Mega J Case Rep. 2024;7(12):2001-2005.
*******
Scholz W. Dose Adjustments in Renal Failure: Does the Dettli Formula Need an Update Moving Away from Linearity?. Austin J Pharmacol Ther. 2024; 12(3): 1192.
*******
Mohamed, F.F.; Anhlan, D.; Schöfbänker, M.; Schreiber, A.; Classen, N.; Hensel, A.; Hempel, G.;
Scholz, W.; Kühn, J.; Hrincius, E.R.; Stephan Ludwig; Hypericum perforatum and Its Ingredients Hypericin and Pseudohypericin Demonstrate an Antiviral Activity against SARSCoV-2. Pharmaceuticals 2022, 15, 530.
https://doi.org/10.3390/ph15050530
*******
Wolfgang Scholz; Bernoulli´s concept of compounding interest and another simple formula to compute Euler's number e; 2/10/2022;
*******
Scholz, W. U. About Pharmacokinetics of Drugs due to Multiple Drug Drug Interactions (MDDI); original in german: Zur Pharmakokinetik von Arzneimitteln bei multiplen Interaktionen – Theoretische Überlegungen und praktische Umsetzung. Krankenhauspharmazie 2016;37:497–505.
Abstract
A theory of multi(ple) drug drug interactions, its impact on the assessment of pharmacokinetics and adverse effects of drugs and its translation into a software calculator to compute dose adjustments in complex drug interaction scenarios
The MDDI (multi drug drug interactions) calculator of SCHOLZ Databank (DIT Drug Database in the USA.) represents a drug drug interaction software which provides a completely new view on interactions and enables the qualitative and quantitative description of multiple pharmacokinetic drug interactions. The vision to realize such a search engine for interactions required to abandon the traditional model of analyzing solely pairs of drugs and to develop a more general theory based on a model of “multi drug drug interactions”.
Please read more in the Download.
*******
Wolfgang Scholz and Stefanie Brune Severe Rhabdomyolysis through concomitant Administration of Simvastatin, Amlodipine, and Ciprofloxacine;
original in german: Schwere Rhabdomyolyse bei Kombination von Simvastatin, Amlodipin und Ciprofloxacin – Interpretation eines Fallberichts mit einer Interaktionssoftware; Arzneimitteltherapie 2016 34(Suppl1):S2-7
Abstract
Severe rhabdomyolysis due to a multi drug drug interaction between simvastatin, amlodipine and ciprofloxacin
A severe drug drug interaction presented in a case report is analyzed using an interaction calculator called “MDDI calculator”.The MDDI (Multi Drug Drug Interactions) calculator provides a completely new view on drug interactions and enables the qualitative and quantitative description of multiple drug interactions with the focus on clearly identifying those drugs the effect or side effect of which is affected by the interplay of multiple other drugs and interaction mechanisms. In the case reported a 41-year old woman, stable on eleven drugs including simvastatin and amlodipine, developed severe rhabdomyolysis after additional use of three antibiotics including ciprofloxacin. Applying the MDDI calculator reveals at a glance that the assessed plasma level increase of simvastatin through the interplay of the weak CYP3A4 inhibitor amlodipine and the moderate CYP3A4 inhibitor ciprofloxacin in particular g.i. can be interpreted very well as the probable cause of the severe rhabdomyolysis reported. With about 10 % of the population in the industrialized countries on polypharmacy the application of efficient tools to analyze multiple drug interactions becomes more and more important and might help doctors and pharmacists to identify and avoid clinically important pharmacokinetic drug interactions even in complex multiple interaction scenarios easily. Key Words: amlodipine, anuria, ciproflocaxin, CYP3A4, DIT Drug Database, multi drug drug interaction, multiple drug interaction, muscle pain, myopathy, rhabdomyolysis, SCHOLZ Datenbank, simvastatin
*******
Wolfgang Scholz and Stefanie Brune Protecting from Falling;
original in german: Vor Stürzen schützen – Sturzprophylaxe mit der SCHOLZ Datenbank; Deutsche Apotheker Zeitung 2016 156, 27:S52-59
*******
Scholz W. SCHOLZ DataBank/Drug Database;
original in german: Scholz- Arzneimittel-Datenbank. Deutsche Apotheker Zeitung 1992;132(14):709–12.
*******
Wolfgang Scholz: Arzneimittelwechselwirkungen (Drug Interactions); Georg Thieme Verlag Stuttgart - New York, 1984, 593 Seiten/pages
*******
Wolfgang Scholz: SCHOLZ-Liste Arzneimittelwechselwirkungen auf einen Blick (Drug Interactions at one Glance); Verlag für Medizinische Information Scholz & Fenner GmbH, München, 1981, 550 Seiten/pages
*******